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pThe single daily dosage may be increased by approximately doubling the dosage at weekly intervals to achieve the desired blood pressure response./ppCaution should be observed when HYTRIN tablets are administered concomitantly with other antihypertensive agentsespecially the calcium channel blocker verapamilto avoid the possibility of developing significant hypotensionWhen using HYTRIN tablets and other antihypertensive agents concomitantlydosage reduction and retitration of either agent may be necessarysee PRECAUTIONSHypotension has been reported when Hytrin has been used with phosphodiesterase-5PDE-5inhibitors./ppThe symptoms associated with BPH are related to bladder outlet obstructionwhich is comprised of two underlying componentsa static component and a dynamic componentThe static component is a consequence of an increase in prostate sizeOver timethe prostate will continue to enlargeHoweverclinical studies have demonstrated that the size of the prostate does not correlate with the severity of BPH symptoms or the degree of urinary obstruction1 The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neckleading to constriction of the bladder outletSmooth muscle tone is mediated by sympathetic nervous stimulation of alpha-l adrenoceptorswhich are abundant in the prostateprostatic capsule and bladder neckThe reduction in symptoms and improvement in urine flow rates following administration of terazosin is related to relaxation of smooth muscle produced by blockade of alpha-l adrenoceptors in the bladder neck and prostateBecause there are relatively few alpha-l adrenoceptors in the bladder bodyterazosin is able to reduce the bladder outlet obstruction without affecting bladder contractility./ppAlthough the exact mechanism of the hypotensive action is not establishedthe relaxation of peripheral blood vessels appears to be produced mainly by competitive antagonism of post-synaptic alpha-adrenoceptorsHytrin usually produces an initial gradual decrease in blood pressure followed by a sustained antihypertensive action./p

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