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pThe combination of ZETIA with a statin is contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levelsWomen who are pregnant or may become pregnantBecause statins decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterolZETIA in combination with a statin may cause fetal harm when administered to pregnant womenAdditionallythere is no apparent benefit to therapy during pregnancyand safety in pregnant women has not been establishedIf the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard to the fetus and the lack of known clinical benefit with continued use during pregnancySee Use in Specific PopulationsNursing mothersBecause statins may pass into breast milkand because statins have the potential to cause serious adverse reactions in nursing infantswomen who require ZETIA treatment in combination with a statin should be advised not to nurse their infantssee Use in Specific PopulationsPatients with a known hypersensitivity to any component of this productHypersensitivity reactions including anaphylaxisangioedemarash and urticaria have been reported with ZETIAsee ADVERSE REACTIONS/ppFrom this studyit may be concluded that addition of ezetimibe has incremental effects on LDL cholesterol reductionIn patients with a high risk of hepatic insufficiencythe addition of ezetimibe to the lowest dose of lovastatin may be helpful in preventing adverse effects of high-dose lovastatin while gaining the full benefits of high-dose lovastatinAlsothe combination of ezetimibe and lovastatin has no greater adverse effects than lovastatin monotherapy7/ppPatients have experienced severe muscle problems while taking ZETIAusually when ZETIA was added to a statin drugIf you experience unexplained muscle paintendernessor weakness while taking ZETIAcontact your doctor immediatelyYou need to do this promptlybecause on rare occasionsthese muscle problems can be seriouswith muscle breakdown resulting in kidney damage./p

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