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pNoradrenaline causes a different sensationWhen levels of this chemical riseit acts as a stimulantemphasising focus and helping the brain to be more alertAnother name for the process of adrenaline release is the fight-or-flight responseIn situations of heightened pressure or dangerthe senses become sharper and more vigilantso that the body is better able to protect itself/ppAs with bupropionvarenicline is not defined in medical terms as a nicotine replacement therapyHoweverit does function in a similar way./ppSmoking is associated with an increase in CYP1A2 activityAfter cessation of smokingreduced clearance of medicinal products metabolised by this enzymewith subsequent increases in plasma levelsmay occurThis may be particularly important for those medicinal products primarily metabolised by CYP1A2 with narrow therapeutic windowse.gtheophyllinetacrine and clozapineThe clinical consequences of smoking cessation on other medicinal products that are partially metabolised by CYP1A2e.gimipramineolanzapineclomipramineand fluvoxamineare unknownIn additionlimited data indicate that the metabolism of flecainide or pentazocine may also be induced by smoking./ppDo not use Zyban if you have used an MAO inhibitor in the past 14 daysA dangerous drug interaction could occurMAO inhibitors include isocarboxazidlinezolidmethylene blue injectionphenelzinerasagilineselegilinetranylcypromineand others./ppBupropion chloride was originally prescribed as an antidepressantIn 1997the FDA approved it as the first medication to help people stop smokingsold under the name Zyban./p

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