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Based on the mechanism of action of snris and ssris, including paroxetine hydrochloride, and the potential for serotonin syndrome, caution is advised when paroxetine hydrochloride controlled-release tablets are coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, linezolid an antibiotic which is a reversible non-selective maoi , lithium, tramadol, or st.
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pSevere nervous system reactionvery stiffrigidmuscleshigh feversweatingconfusionfast or uneven heartbeatstremorsfaintingor./ppWorsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy./ppPaxil CR12.5 mg orally once/day initiallymay increase at 1-week intervals not to exceed 25 mg/day./ppPaxil CR12.5 mg PO qDay initiallymay increase at 1 week intervals not to exceed 25 mg/day./ppTell your doctor and pharmacist if you are allergic to paroxetineany other medicationsor any of the ingredients in paroxetine tabletscontrolled-release tabletscapsulesor suspensionAsk your pharmacist or check the Medication Guide for a list of the ingredients tell your doctor if you are taking monoamine oxidaseMAOinhibitorsincluding isocarboxazidMarplanlinezolidZyvoxmethylene bluephenelzineNardilselegilineEldeprylEmsamZelaparand tranylcypromineParnateif you have stopped taking them within the past 2 weeksor if you are taking thioridazine or pimozideOrapYour doctor will probably tell you not to take paroxetineIf you stop taking paroxetineyou should wait at least 2 weeks before you start to take an MAO inhibitortell your doctor and pharmacist what other prescription and nonprescription medications and vitamins you are taking or plan to takeBe sure to mention any of the followinganticoagulantsblood thinnerssuch as warfarinCoumadinantidepressantsmood elevatorssuch as amitriptylineElavilamoxapineAsendinclomipramineAnafranildesipramineNorpramindoxepinAdapinSinequanimipramineTofranilnortriptylineAventylPamelorprotriptylineVivactiland trimipramineSurmontilantihistaminesaspirin and other nonsteroidal anti-inflammatory drugsNSAIDssuch as ibuprofenAdvilMotrinand naproxenAleveNaprosynatomoxetineStraterraatazanavirReyatazbromocriptineParlodelbupropionWellbutrinbuspironeBusparcelecoxibCelebrexchlorpromazineThorazinecimetidineTagametclopidogrelPlavixcodeinefound in many cough and pain 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stomach or esophagustube that connects the mouth and stomachor liverkidneyor heart diseasetell your doctor if you are pregnantif you plan to become pregnantor if you are breast-feedingIf you become pregnant while taking paroxetinecall your doctor immediatelyParoxetine may cause heart defects in the fetus if it is taken during early pregnancy and problems in newborns following delivery if it is taken during the last months of pregnancyif you are having surgeryincluding dental surgery tell the doctor or dentist that you are taking paroxetineyou should know that paroxetine may make you drowsy and affect your judgment and thinkingDo not drive a car or operate machinery until you know how this medication affects youask your doctor about the safe use of alcoholic beverages while you are taking paroxetineyou should know that paroxetine may cause angle-closure glaucomaa condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quicksevere increase in eye pressure which may lead to a loss of visionTalk to your doctor about having an eye examination before you start taking this medicationIf you have nauseaeye painchanges in visionsuch as seeing colored rings around lightsand swelling or redness in or around the eyecall your doctor or get emergency medical treatment right away./p

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