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pAlthough some nonconjugated metabolites have pharmacologic activitythese are not found in plasma at concentrations likely to significantly contribute to the biological activity of ondansetron./ppZOFRAN is indicated for the prevention of nausea and vomiting associated with:/ppFlushingRare cases of hypersensitivity reactionssometimes severee.ganaphylactic reactionsangioedemabronchospasmshortness of breathhypotensionlaryngeal edemastridorhave also been reportedLaryngospasmshockand cardiopulmonary arrest have occurred during allergic reactions in patients receiving injectable ondansetron./p

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