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pThe active substance in Viramunenevirapineis a non-nucleoside reverse-transcriptase inhibitorNNRTIIt blocks the activity of reverse transcriptasean enzyme produced by HIV-1 that allows it to infect cells in the body and make more virusesBy blocking this enzymeViramunetaken in combination with other antiviral medicinesreduces the amount of HIV-1 in the blood and keeps it at a low levelViramune does not cure HIV-1 infection or AIDSbut it may delay the damage to the immune system and the development of infections and diseases associated with AIDS./ppCaution should be exercised when co-administering telaprevir with nevirapine./ppPost-Exposure-ProphylaxisSerious hepatotoxicityincluding liver failure requiring transplantationhas been reported in HIV-uninfected individuals receiving multiple doses of Viramune in the setting of post-exposure-prophylaxisPEPan unapproved useThe use of Viramune has not been evaluated within a specific study on PEPespecially in term of treatment duration and thereforeis strongly discouraged./ppRisk of immune reconstitution syndrome if used in combination with other antiretroviral drugs./ppIf clinical hepatitis occurscharacterised by anorexianauseavomitingicterus AND laboratory findingssuch as moderate or severe liver function test abnormalitiesexcluding GGTnevirapine must be permanently stoppedViramune must not be readministered to patients who have required permanent discontinuation for clinical hepatitis due to nevirapine./p

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